Methadone, sold under the brand name Dolophine among others, is an opioid used to treat pain and as maintenance therapy or to help with tapering in people with opioid dependence.
Excretion: Urine, faeces
Bioavailability: 41–99% (by mouth)
Onset of action: Rapid
Trade name: Dolophine, Methadose, others
Metabolism: Liver (CYP3A4, CYP2B6 and CYP2D6-mediated)
Biological half-life: 15 to 55 hours
Nitrazepam (brand names Alodorm and Mogadon, among others) is a hypnotic drug of the benzodiazepine class used for short-term relief from severe, disabling anxiety and insomnia. It also has sedative (calming) properties, as well as amnestic (inducing forgetfulness), anticonvulsant, and skeletal muscle relaxant effects
Nitrazepam is used to treat short-term sleeping problems (insomnia), namely difficulty falling asleep, frequent awakening, early awakening, or a combination of each.
Nitrazepam is sometimes tried to treat epilepsy when other medications fail. It has been found to be more effective than clonazepam in the treatment of West syndrome, which is an age-dependent epilepsy, affecting the very young. In uncontrolled studies, nitrazepam has shown effectiveness in infantile spasms and is sometimes considered when other anti-seizure drugs have failed. However, drowsiness, hypotonia, and most significantly tolerance to anti-seizure effects typically develop with long term treatment, generally limiting Nitrazepam to acute seizure management